The Hotel Anessis is located in the central city zone. Guests will be able to walk to the museums, Byzantine cathedral, or the White Tower. Alternatively, guests have the main market square, the Tsimiski shopping street, and the harbor boutiques also as pedestrian destinations. The Hotel Anessis is less than 10 minutes from the main train terminal in the city center. It is just under 20 minutes' drive from the hotel to the international airport.

There are 49 rooms at the Hotel Anessis, designed as standard rooms. Rooms have modern décor, individualized heating and cooling, high speed Internet access, satellite television service, direct dial telephones, and en suite bathrooms. Non-smoking rooms are available. Non-smoking areas at the hotel are designated.

The Hotel Anessis is a modern property that was renovated in 2006. The front desk staff provide tourist support services and light business services support. Room service is available 24 hours a day to ensure guests comfort. Wireless Internet access is offered free of charge throughout the facility.